Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 41 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
7
Vitamin E (as dl-Alpha tocopheryl acetate)
68 mg
453%
Coenzyme Q10
100 mg
**
Top Medical Research Studies
9
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
Read More
This study focused on the potential protective effects of Coenzyme Q10 (CoQ10) against heart damage caused by copper toxicity. We induced myocardial injury in rats using daily doses of copper sulfate for a week, observing detrimental effects on heart function.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
Read More
9
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Read More
Most Useful Reviews
9
Supports heart health
16 people found this helpful
Excellent for heart health. My elderly parents adore this CoQ10 brand, valuable for their heart disease, high cholesterol, and blood pressure management. I too have benefited when feeling fatigued; it provides a boost I can't get from multivitamins. Our family wholeheartedly recommends this product, as it is well-absorbed compared to regular CoQ10 forms.
Read More
9
Prevents heart enlargement
15 people found this helpful
Qunol CoQ10 is the best! I’ve used it for ages after experiencing congestive heart failure. My doctor believes it has helped prevent my heart from becoming enlarged, keeping it flexible – which he noted is quite rare. I make sure I never run out of it.
Read More
10
Long-term heart health
1 people found this helpful
My old heart keeps going thanks to this supplement. I highly recommend it for anyone concerned about heart disease, as I've trusted it for over 20 years.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
- All Researches
9
We aimed to investigate the effects of Coenzyme Q10 (CoQ10) on heart health in the context of CDKL5 deficiency disorder (CDD). CDD is a complex condition caused by mutations in the CDKL5 gene, leading to severe developmental challenges and systemic issues, including oxidative stress.
Our study demonstrated that CoQ10 supplementation can significantly reduce harmful levels of reactive oxygen species (ROS) and help restore a balanced state of glutathione in the body. This is important because oxidative stress is believed to contribute to various health problems, including those affecting the heart.
Additionally, we found that CoQ10 not only improved markers of cellular health and proliferation in a human neuron model but also provided protective effects against lipid peroxidation and DNA damage in the hearts of a mouse model of CDD.
Overall, our findings suggest that CoQ10 may play a crucial role in alleviating oxidative stress and protecting heart health in individuals with CDD, offering a potential therapeutic avenue worth exploring further.
Our study demonstrated that CoQ10 supplementation can significantly reduce harmful levels of reactive oxygen species (ROS) and help restore a balanced state of glutathione in the body. This is important because oxidative stress is believed to contribute to various health problems, including those affecting the heart.
Additionally, we found that CoQ10 not only improved markers of cellular health and proliferation in a human neuron model but also provided protective effects against lipid peroxidation and DNA damage in the hearts of a mouse model of CDD.
Overall, our findings suggest that CoQ10 may play a crucial role in alleviating oxidative stress and protecting heart health in individuals with CDD, offering a potential therapeutic avenue worth exploring further.
Read More
This study focused on the potential protective effects of Coenzyme Q10 (CoQ10) against heart damage caused by copper toxicity. We induced myocardial injury in rats using daily doses of copper sulfate for a week, observing detrimental effects on heart function.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
Read More
9
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Read More
9
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.
However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.
In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
Read More
9
CoQ10 mitigates chemotherapy-related heart damage
We aimed to explore the effects of Coenzyme Q10 (CoQ10) on heart health in the context of Doxorubicin treatment, a common chemotherapy known for its side effects, including heart damage. Our study involved 27 white albino rats, which we divided into three groups: one receiving CoQ10, another receiving Doxorubicin, and a final group receiving both treatments.
After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.
However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.
Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.
However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.
Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
Read More
User Reviews
USERS' SCORE
Good
Based on 41 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports heart health
16 people found this helpful
Excellent for heart health. My elderly parents adore this CoQ10 brand, valuable for their heart disease, high cholesterol, and blood pressure management. I too have benefited when feeling fatigued; it provides a boost I can't get from multivitamins. Our family wholeheartedly recommends this product, as it is well-absorbed compared to regular CoQ10 forms.
Read More
9
Prevents heart enlargement
15 people found this helpful
Qunol CoQ10 is the best! I’ve used it for ages after experiencing congestive heart failure. My doctor believes it has helped prevent my heart from becoming enlarged, keeping it flexible – which he noted is quite rare. I make sure I never run out of it.
Read More
10
Long-term heart health
1 people found this helpful
My old heart keeps going thanks to this supplement. I highly recommend it for anyone concerned about heart disease, as I've trusted it for over 20 years.
Read More
9
Supports heart failure
1 people found this helpful
Excellent product for supporting my heart failure and arrhythmia! It has been instrumental in my health management.
Read More
9
Strong heart support
1 people found this helpful
My heart is strong and healthy thanks to Qunol. My doctor recommended it years ago for heart disease.
Read More
Frequently Asked Questions
9
Normalised heartbeat
1 people found this helpful
This product has helped normalise my husband's elevated heart rate after just one daily dose. It also enhances energy and concentration, crucial for heart disease management.
9
Reduced cholesterol levels
1 people found this helpful
This supplement is excellent for heart disease. After six months, my health checks showed my triglycerides and cholesterol levels were reduced to standard levels. I have repurchased it multiple times and will continue doing so.
9
Comprehensive support
1 people found this helpful
This premium supplement is a comprehensive antioxidant supporting energy and tissue health. It provides excellent support for heart disease and brain tissues.
9
Supports heart health
1 people found this helpful
This supplement is essential for my heart. I have been taking Qunol for years.
7.5
Palpitations reduced
2 people found this helpful
It's effective, as recommended by my cardiac surgeon. My heart palpitations diminished, and my pulse steadied. I believe it’s doing its job.
9
Supports heart health
16 people found this helpful
Excellent for heart health. My elderly parents adore this CoQ10 brand, valuable for their heart disease, high cholesterol, and blood pressure management. I too have benefited when feeling fatigued; it provides a boost I can't get from multivitamins. Our family wholeheartedly recommends this product, as it is well-absorbed compared to regular CoQ10 forms.
7.5
Improved mood
9 people found this helpful
I ordered this for my grandfather, who was depressed and uninterested in family. After two weeks on one capsule daily, along with alpha-lipoic acid, his mood markedly improved. Grandpa even shared it with his wife with Alzheimer's; she too noticed a change. We are incredibly pleased after trying many alternatives, and I’ll reorder.
7.5
Heart functioning support
4 people found this helpful
A fantastic prophylactic dosage and a powerful antioxidant, CoQ10 is essential for heart health and maintains youthful skin. I take it alongside vitamin D and fish oil for better absorption with fat-soluble vitamins. I recommend it to anyone concerned about their heart disease.
9
Absorbable and safe
1 people found this helpful
I highly recommend Coenzyme Q10 from Qnol. I've taken it for several years, particularly because I take statins, which deplete this essential nutrient, preventing potential heart disease issues.
9
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.
Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.
Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
This study focused on the potential protective effects of Coenzyme Q10 (CoQ10) against heart damage caused by copper toxicity. We induced myocardial injury in rats using daily doses of copper sulfate for a week, observing detrimental effects on heart function.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.
Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.
Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
9
CoQ10 mitigates chemotherapy-related heart damage
We aimed to explore the effects of Coenzyme Q10 (CoQ10) on heart health in the context of Doxorubicin treatment, a common chemotherapy known for its side effects, including heart damage. Our study involved 27 white albino rats, which we divided into three groups: one receiving CoQ10, another receiving Doxorubicin, and a final group receiving both treatments.
After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.
However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.
Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.
However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.
Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
We explored how Coenzyme Q10 (CoQ10) combined with ultrasound-targeted microbubble destruction (UTMD) could help treat diabetic cardiomyopathy (DCM) in rats. In our study, we took a close look at the heart health of diabetic rats after using these innovative treatments. Specifically, we used a group of 60 male rats, inducing diabetes in most of them and setting up control groups for comparison.
After treating the rats for 12 weeks, we observed that the group receiving CoQ10 encapsulated in nanoliposomes combined with UTMD showed promising signs of improvement. Notably, their heart structure appeared intact, and they had improved heart function metrics like left ventricular dimensions. We found significant reductions in harmful indicators of heart stress and damage among the treatment group compared to those not receiving the combined therapy.
It's important to mention that while CoQ10 seemed beneficial in this context, the study did not isolate the effects of CoQ10 alone. This means we cannot definitively conclude its exclusive role without considering the combined effect with UTMD. Overall, our findings indicate that CoQ10, especially with the support of advanced delivery techniques, can contribute to better heart health in diabetes-affected conditions.
After treating the rats for 12 weeks, we observed that the group receiving CoQ10 encapsulated in nanoliposomes combined with UTMD showed promising signs of improvement. Notably, their heart structure appeared intact, and they had improved heart function metrics like left ventricular dimensions. We found significant reductions in harmful indicators of heart stress and damage among the treatment group compared to those not receiving the combined therapy.
It's important to mention that while CoQ10 seemed beneficial in this context, the study did not isolate the effects of CoQ10 alone. This means we cannot definitively conclude its exclusive role without considering the combined effect with UTMD. Overall, our findings indicate that CoQ10, especially with the support of advanced delivery techniques, can contribute to better heart health in diabetes-affected conditions.
7
We explored the effects of coenzyme Q10 (CoQ10) on heart disease, particularly in relation to diabetic cardiomyopathy, a common complication for those with diabetes. The study discussed various treatment options for heart issues stemming from diabetes, highlighting how CoQ10 might play a role.
While CoQ10 has shown promise in some areas of heart health, the study indicates it does not deliver clear benefits when isolated from other treatments. This suggests that while it may be part of a broader treatment strategy, relying solely on CoQ10 for heart disease management may not be effective.
In addition to CoQ10, we noted the importance of lifestyle changes such as maintaining a healthy diet and engaging in regular physical activity. These factors are crucial in combatting the progression of diabetic cardiomyopathy and improving overall heart health.
While CoQ10 has shown promise in some areas of heart health, the study indicates it does not deliver clear benefits when isolated from other treatments. This suggests that while it may be part of a broader treatment strategy, relying solely on CoQ10 for heart disease management may not be effective.
In addition to CoQ10, we noted the importance of lifestyle changes such as maintaining a healthy diet and engaging in regular physical activity. These factors are crucial in combatting the progression of diabetic cardiomyopathy and improving overall heart health.
4
Ubiquinone shows mixed heart surgery effects
In our exploration of how coenzyme Q10, also known as ubiquinone, affects outcomes for patients undergoing cardiac surgery, we analyzed its potential benefits in preventing acute kidney injury (AKI). This condition is a significant concern, impacting nearly half of the patients after heart surgery due to factors like ischemia-reperfusion injury and oxidative stress.
For this study, we compared a group of patients who received high doses of ubiquinone—8 mg per kg per day, divided into three doses—with a control group given a placebo. While the intervention did not lead to a significant reduction in the incidence of cardiac surgery-related acute kidney injury, we noted some interesting secondary outcomes. Patients who took ubiquinone experienced less postoperative bleeding and lower levels of a specific heart protein (hs-TnI) indicating less heart damage.
Although ubiquinone didn’t demonstrate a clear advantage in preventing kidney injury, its effect on reducing postoperative bleeding and heart stress markers suggests there may still be beneficial aspects worth further exploration. This study provides a foundation for considering how coenzyme Q10 might play a role in enhancing recovery after heart surgery, even if its effects on kidney injury were not significant.
For this study, we compared a group of patients who received high doses of ubiquinone—8 mg per kg per day, divided into three doses—with a control group given a placebo. While the intervention did not lead to a significant reduction in the incidence of cardiac surgery-related acute kidney injury, we noted some interesting secondary outcomes. Patients who took ubiquinone experienced less postoperative bleeding and lower levels of a specific heart protein (hs-TnI) indicating less heart damage.
Although ubiquinone didn’t demonstrate a clear advantage in preventing kidney injury, its effect on reducing postoperative bleeding and heart stress markers suggests there may still be beneficial aspects worth further exploration. This study provides a foundation for considering how coenzyme Q10 might play a role in enhancing recovery after heart surgery, even if its effects on kidney injury were not significant.
References
- Loi M, Valenti F, Medici G, Mottolese N, Candini G, et al. Beneficial Antioxidant Effects of Coenzyme Q10 in In Vitro and In Vivo Models of CDKL5 Deficiency Disorder. Int J Mol Sci. 2025;26. doi:10.3390/ijms26052204
- Vučemilović H, Kovač R, Stanišić L, Sanader Vučemilović A, Mrčela D, et al. Is High-Dose Ubiquinone Therapy Before Cardiac Surgery Enough to Reduce the Incidence of Cardiac Surgery-Associated Acute Kidney Injury? A Randomized Controlled Trial. Antioxidants (Basel). 2025;14. doi:10.3390/antiox14020243
- Alghibiwi HK, Alhusiani AM, Sarawi WS, Fadda L, Alomar HA, et al. Coenzyme Q10 and its liposomal form prevent copper cardiotoxicity by attenuating oxidative stress, TLR-4/NF-κB signaling and necroptosis in rats. Cell Mol Biol (Noisy-le-grand). 2025;71:118. doi:10.14715/cmb/2025.70.1.13
- Zhang M, Sun MY, He WY, Yu SF, Ma WC. [Experimental study on the treatment of diabetic cardiomyopathy in rats by using ultrasound-targeted microbubble destruction combined with coenzyme Q10 loaded long-circulating nanoliposomes]. Zhonghua Yi Xue Za Zhi. 2024;104:3765. doi:10.3760/cma.j.cn112137-20240605-01273
- Xu J, Xiang L, Yin X, Song H, Chen C, et al. Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. 2024;24:592. doi:10.1186/s12872-024-04232-z
- Guo Z, Tian Y, Liu N, Chen Y, Chen X, et al. Mitochondrial Stress as a Central Player in the Pathogenesis of Hypoxia-Related Myocardial Dysfunction: New Insights. Int J Med Sci. 2024;21:2502. doi:10.7150/ijms.99359
- Qazi SU, Bin Naeem MA, Umar M, Zahid MJ, Kan Changez MI, et al. Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis. Future Cardiol. 2024;20:221. doi:10.1080/14796678.2024.2352308
- Intan RE, Balti DR, Nugraha RA, Alkaff FF, Salamah S, et al. Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report. J Pak Med Assoc. 2024;74:S81. doi:10.47391/JPMA.S6-ACSA-16
- Ali S, Sulaiman E, Dhiaa S. HISTOLOGICAL EFFECTS OF CO ENZYME Q10 ON DOXORUBICIN-INDUCED DEFICITS OF CARDIOPULMONARY AXIS IN WHITE ALBINO RATS. Georgian Med News. 2024.
- Alehagen U, Aaseth J, Schomburg L, Larsson A, Opstad T, et al. Selenoprotein P increases upon selenium and coenzyme Q supplementation and is associated with telomere length, quality of life and reduced inflammation and mortality. Free Radic Biol Med. 2024;222:403. doi:10.1016/j.freeradbiomed.2024.06.027
- Zeng M, Chen Z, Zhang Y, Pang Y. Combination of trimetazidine and coenzyme Q10 for the treatment of acute viral myocarditis: a systematic review and meta-analysis. J Infect Dev Ctries. 2024;18:658. doi:10.3855/jidc.18776
- Du H, Zhao Y, Wen J, Dai B, Hu G, et al. LncRNA DCRT Protects Against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1. Circulation. 2024;150:1030. doi:10.1161/CIRCULATIONAHA.123.067861
- Graczyk P, Dach A, Dyrka K, Pawlik A. Pathophysiology and Advances in the Therapy of Cardiomyopathy in Patients with Diabetes Mellitus. Int J Mol Sci. 2024;25. doi:10.3390/ijms25095027
- Alehagen U, Alexander J, Aaseth JO, Larsson A, Opstad TB. Supplementation with selenium and coenzyme Q in an elderly Swedish population low in selenium - positive effects on thyroid hormones, cardiovascular mortality, and quality of life. BMC Med. 2024;22:191. doi:10.1186/s12916-024-03411-1
- Antar SA, Abdo W, Helal AI, Abduh MS, Hakami ZH, et al. Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-κB/NLRP3 inflammasome axis and attenuating oxidative stress in mice. Life Sci. 2024;348:122688. doi:10.1016/j.lfs.2024.122688
- Seo JS. Chronological change of left ventricular global longitudinal strain in patients with maternally inherited diabetes and deafness: A case series. Medicine (Baltimore). 2024;103:e37447. doi:10.1097/MD.0000000000037447
